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Wednesday, April 22 • 2:30pm - 4:30pm
Phenstatin analogues with non-aromatic attachments in place of the B-ring

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Phenstatin derivatives are cancer-fighting analogues of the naturally occurring molecules colchicine and combretastatin (CA-4). These species of molecules are able to bind to alpha- and beta-receptors of microtubules to halt cell division. Some research groups have observed that adding a phenothiazine in place of the A-ring and an indole in location of the B-ring increased anti-cancer activity. Recent studies of phenstatin derivatives containing phenothiazine and indole functionalities have shown that size and torsional strain affect the toxicity towards cancer cells and the molecules ability to attach to microtubulin. This research focuses on attaching a phenothiazine molecule in location of the A-ring and different sized non-aromatic rings in place of the B-ring to determine if strain and size affect binding to the microtubule surface.


Wednesday April 22, 2015 2:30pm - 4:30pm PDT
Wilma Sherrill Center Grimes Atrium

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