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Wednesday, April 22 • 2:30pm - 4:30pm
Cross-Species Induction of Antibacterial Compounds Produced by Interaction of Pseudomonas stutzeri Against Invading Microorganisms

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New avenues for drug discovery are in demand due to increasing amounts of drug-resistant bacterial strains. Although multidrug resistant bacteria have become an increasing global threat, the discovery of new antibiotics with novel mechanisms of action has slowed over the last 20 years. Co-culturing bacteria strains is a relatively new method to induce the production of novel antibacterial natural products that can be isolated for further research. Combining diverse bacteria may influence expression of secondary metabolite antibiotics unseen in standard laboratory conditions. The aim of this project is to co-culture the known producer, Pseudomonas stutzeri, and unidentified soil bacteria to elicit the production of small molecule natural products with antibiotic activity against Staphylococcus aureus and Escherichia coli. The small molecules will then be isolated and characterized using 1H and 13C NMR, IR, and mass spectrometry. To date, various culture conditions have been explored to achieve optimal growth for both bacteria strains in the combined setting. An environment promoting co-cultured bacteria will lead to secondary metabolite production and the discovery of active compounds that inhibit S. aureus and E. coli proliferation.


Wednesday April 22, 2015 2:30pm - 4:30pm PDT
Wilma Sherrill Center Grimes Atrium